New NANOCI publications

The NANOCI project is now on the home straight and the validation of the final device is well under way. The animal-grade cochlear implant includes all the individual components developed in the course of the project. For example, new electrodes with superior electrical characteristics have been designed, novel neurotrophins can be released in a gel like matrix to stimulate regrowth of nerve fibres and antimicrobial nanoparticles were added.

Results of the validation are keenly awaited by the team and should be available in Autumn 2015 on this website. Over the course of the last months eight peer-reviewed articles which were published in 2015 and focus on individual aspects of NANOCI were added to the NANOCI publication list:

  1. Auditory Nerve Preservation and Regeneration in Man - Relevance for Cochlear Implantation. Helge Rask-Andersen and Wei Li. Neural Regeneration Research, 10(5), 710-712–65, 2015. doi:10.4103/1673-5374.156963
  2. X-ray microtomographic confirmation of the reliability of CBCT in identifying the scalar location of cochlear implant electrode after round window insertion. Zou J, Hannula M, Lehto K, Feng H, Lähelmä J, Aula AS, Hyttinen J, Pyykkö I. Hearing Research, 326, 59–65, 2015. doi:10.1016/j.heares.2015.04.005
  3. Solid on liquid deposition, a review of technological solutions. Alexandra Homsy, Edith Laux, Laure Jeandupeux, Jerome Charmet, Roland Bitterli, Chiara Botta, Yves Rebetez, Oksana Banakh, H. Keppner. Microelectronic Engineering, 141, 267–79, 2015. doi:10.1016/j.mee.2015.03.068
  4. Imaging cochlear implantation with round window insertion in human temporal bones and cochlear morphological variation using high-resolution cone beam CT. Zou J, Lähelmä J, Koivisto J, Dhanasingh A, Jolly C, Aarnisalo A, Wolff J, Pyykkö I. Acta Otolaryngol. 135(5), 466-472, 2015. doi:10.3109/00016489.2014.993090
  5. Macromolecular organization and fine structure of the human basilar membrane - RELEVANCE for cochlear implantation. Wei Liu, Francesca Atturo, Robair Aldaya, Peter Santi, Sebahattin Cureoglu, Sabrina Obwegeser, Rudolf Glueckert, Kristian Pfaller, Annelies Schrott-Fischer and Helge Rask-Andersen. Cell Tissue Res. 360(2), 245–262, 2015. doi:10.1007/s00441-014-2098-z
  6. Imaging Optimization of Temporal Bones With Cochlear Implant Using a High-resolution Cone Beam CT and the Corresponding Effective Dose. Jing Zou, Juha Koivisto, Jaakko Lähelmä, Antti Aarnisalo, Jan Wolff, and Ilmari Pyykkö. Ann Otol Rhinol Laryngol 124(6) 466-473, 2015. doi:10.1177/0003489414565004
  7. MeV ion beam lithography of biocompatible halogenated Parylenes using aperture masks. Harry J. Whitlow, Rattanaporn Norarat, Marta Roccio, Patrick Jeanneret, Edouard Guibert, Maxime Bergamin, Gianni Fiorucci, Alexandra Homsy, Edith Laux, Herbert Keppner, Pascal Senn. Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms. 354, 34–36, 2015. doi:10.1016/j.nimb.2014.10.024
  8. The pre- and post-somatic segments of the human type I spiral ganglion neurons – Structural and functional considerations related to cochlear implantation. W. Liu , F. Edin , F. Atturo , G. Rieger , H. Löwenheim , P. Senn , M. Blumer , A. Schrott-Fischer , H. Rask-Andersen , R. Glueckert. Neuroscience, 284, 470-482, 2015. doi:10.1016/j.neuroscience.2014.09.059

NANOCI results overview

Whilst the development of the NANOCI prototype device is under construction, we present an overview of the results of the first 18 months of the project.

See also the list of publications issued by the project. More publications are in preparation.